Chinese Journal of Health Statistics 2009;(5):477-479,482
doi:10.3969/j.issn.1002-3674.2009.05.008
Comparison of Blinding Sample Size Adjustment with Unblinding One in Clinical Trials Through Simulations
Suzhen WANG ; Jielai XIA ; Liang ZHENG
Keywords
RCT; Type I error inflation; Adaptive de-sign; Monte Carlo simulation
Country
China
Language
Chinese
Abstract
Objective To determine the appropriate methods to sample size adjustment for adaptive design through simulations by comparing sample size adjustment of blinding internal pilot design with that of unwinding one in clinical trials. Methods Compare type I error and the power of blinding and unblinding internal pilot design through Monte Carlo simulation. Results Either type I error rates or the powers are not substantially distinct in two lands of settings. Conclusion Blinding sample size adjustment is more preferable.
备案号: 11010502037788, 京ICP备10218182号-8)