Study on BET in sodium bicarbonate injection with TAL

Xiaomeng ZHAO; Jiejiao YANG; Yongquan ZHU

Chinese Pharmaceutical Journal 1999;(2):116-

Xiaomeng ZHAO ; Jiejiao YANG ; Yongquan ZHU

Keywords

sodium bicarbonate injection; inhibition/strengthen test; bacterial endotoxins test; pyrogen test

Country

China

Language

Chinese

Abstract

OBJECTIVE:To determine whether bacterial endotoxins test(BET) can replace the pyrogen test for the sodium bicarbonate injection.METHODS:The comparative experiment of tachypleus amebocyte lysate(TAL) and rabbits were studied to determine the sensitivity.RESULTS:The sensitivity of TAL test was 0.125 EU.ml－1, 12 times higher than that of using rabbits.CONCLUSIONS:BET may replace pyrogen test.

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