Journal of International Oncology 2010;37(1):40-42,75

doi:10.3760/cma.j.issn.1673-422X.2010.01.013

Advancement of molecular targeted therapies in squamous cell carcinoma of head and neck

Zhengcai LI

Keywords

Head and neck neoplasms; Carcinoma,squamous cell; Epidermal growth factor; Vascular endothelial growth factor

Country

China

Language

Chinese

Abstract

Current reseach of molecular targeted therapies in squamous cell carcinoma of head and neck(SCCHN) is particularly active.As epidermal growth factor receptor(EGFR) signaling pathway and angiogenesis play a key role in the growth of SCCHN,EGFR with its downstream effectors and molecular factors implicated in the angiogenesis process,such as vascular endothelial growth factor and its receptors,represent the main targets of new therapeutic agents now.