Chinese Journal of Hypertension 2006;0(08):-

Fibrinolytic Dysfunction After A High-fat Meal Induced Postprandial Triglyceride and Inflammatory Responses in Normocholesterolemic Patients with Essential Hypertension

Ling LIU ; Shuiping ZHAO ; Hongnian ZHOU ; Min HU ; Jixiang LI

Keywords

High-fat meal; Hypertension; Inflammation; Endothelium; Fibrinolytic dysfunction

Country

China

Language

Chinese

Abstract

Objective To explore the potential influence of a high-fat meal on systemic inflammation and fibrinolytic dysfunction in normocholesterolemic patients with essential hypertension(EH).Methods Plasma concentrations of lipids profiles,high-sensitivity C-reactive protein(hsCRP),plasminogen activator inhibitor type 1(PAI-1)and tissue plasminogen activator(t-PA)antigens in fasting state(F)and at 4 hours after a single high-fat meal(P)were measured in 54 EH patients and 30 healthy controls(Con).Results Postprandial triglyceride concentrations increased significantly in both hypertensive patients and healthy controls(P