Chinese Journal of Hypertension 2007;0(03):-

Sodium Channel Current In Hypertrophied Myocardiocytes in Spontaneously hypertensive Rat

Zhibin HUANG ; Wei WU ; Chang FANG ; Yulin WEI

Keywords

Hypertension; Left ventricular hypertrophy; Ionic channel; Sodium channel

Country

China

Language

Chinese

Abstract

Objective To study the change in sodium channel current(ⅠNa)in the developement of the left ventricular hypertrophy in spontaneously hypertensive rat(SHR).Methods ⅠNa and membrane capacitance(MC)were measured in myocytes of 10,24 and 34-week SHR by the whole-cell patch-clamp technique.Systolic blood pressure(SBP)and left ventricular mass index(LVMI)were detemined.10-week old Wistar rats served as controls.Results LVMI and MC of SHR were significantly higher than those of Wistar rat(P0.05),however the density of ⅠNain 34-week SHR were higher than those of Wistar rat(-18.3?1.9)vs(-15.3?2.0)pA/pF,P