Journal of Korean Neuropsychiatric Association  2002;41(4):630-637

Association between Dopamine Receptor D4 Polymorphisms and Novelty Seeking Personality Trait in a Korean Population.

Heon Jeong LEE 1 ; Hong Seock LEE ; Hwa Yeon KANG ; Leen KIM ; Min Soo LEE ; Kwang Yoon SUH ; Young Chan BYUN

Affiliations

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Keywords

Novelty seeking; Polymorphism; DRD4

Country

Republic of Korea

Language

Korean

Abstract

OBJECTIVES: We investigated the relationship of personality traits with dopamine D4 receptor(DRD4) exon III polymorphism in a Korean population. METHODS: We analysed DRD4 exon III 48-bp repeats polymorphism in 173 Korean healthy female adolescents(age=13.88+/-0.29 years) who also completed Temperament and Character Inventory(TCI). RESULTS: Novelty seeking score of the TCI was significantly higher in the subjects with DRD4 long alleles(>or=5 repeats) compared with the subjects without these(t=2.11, p=0.037). CONCLUSION: The present study supports the previous reports that long repeats of the DRD4-exon III polymorphism are related with Novelty Seeking personality.