Progress in Biochemistry and Biophysics 2006;0(12):-

Gadd45a Function in Suppressing Cell Transformation and Tumor Malignancy

Junfang JI ; Min WU ; Qimin ZHAN

Keywords

Gadd45a, genomic stability, tumor

Country

China

Language

Chinese

Abstract

Gadd45a, a p53 and BRCA1-regulated growth arrest and DNA damage gene, plays important roles in suppressing cell transformation and tumor malignancy. Gadd45a maintains the genomic stability through inhibiting the cell growth and promoting the DNA repair etc, by which it suppresses the tumor development. Additionally, Gadd45a is involved in some important signaling pathway, contributing to its function in tumor suppressing.