Chinese Journal of Hypertension 2006;0(12):-

Combined Ferulic acid and Perinopril Treatment in Essential Hypertension

Xiaojun WANG ; Wenzeng HUANG ; Buyan ZHANG

Keywords

Chuanxiongsu; Perindopril; Essential Hypertension; Blood Pressure; Endothelin-1; Nitric Oxide

Country

China

Language

Chinese

Abstract

Objective Study the effect of Chuanxiongsu(ferulic acid) combined perindopril or perindopril alone in the treatment of essential hypertension (EH). Methods Sixty patients with EH were divided into two groups randomly and single blindly: group A received Chuanxiongsu combined with perindopril, while group B received perindopril alone(4-8 mg/d) only for four weeks. Plasma endothelin-1 concentration(ET-1) and nitric oxide (NO) concentration were determined with radiommunoassay(RIA). Blood pressure was monitored before and after treatment. Thirty healthy volunteers served as controls. Results SBP in group A was lower than that in group B(138.9?8.1 vs group B 143.1?8.5)mm Hg, P