Journal of the Korean Society of Pediatric Nephrology  2002;6(1):120-122

A Case of Hemolysis after Minor ABO Mismatched Kidney Transplantation.

Hye Won HAHN 1 ; Il Soo HA ; Hae Il CHEONG ; Yong CHOI

Affiliations

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Keywords

Hemolysis; ABO mismatched kidney transplatation; Autoantibody

Country

Republic of Korea

Language

English

Abstract

A 9-year-old boy of B blood group with end-stage renal disease due to IgA nephropathy received group O kidney transplantation from his father. On day 9, he developed intravascular hemolysis, and anti-B autoantibody formation was confirmed. We diagnosed as immune hemolytic anemia due to passenger lymphocyte from donor, and cyclosporine withdrawl was done. Anemia resolved spontaneously, but on day 18, graft dysfunction developed, and graft biopsy revealed acute allograft rejection. Although hemolysis due to autoantibody is very rare and often mild, and the role of hemoglobinuria on acute rejection in this case is not certain, we recommend consideration of aggressive management on severe hemolysis after minor mismatched kidney transplantation.