Journal of Jilin University(Medicine Edition) 2006;0(01):-

Expressions of matrix metalloproteinases-2 and its tissue inhibitor-2 and microvessel density in endometrial carcinoma

Yujing ZHANG ; Liping GU ; Ying HUA ; Shoujie ZHANG

Keywords

endometrial neoplasms; gelatinase A; tissue inhibitor of metalloproteinases; neovascularization, pathologic; micro vascular density

Country

China

Language

Chinese

Abstract

Objective To study the expressions of matrix metalloproteinases-2 (MMP-2) and its tissue inhibitor-2 (TIMP-2) and microvessel density (MVD) in human endometrial carcinoma tissues and their relations with the invasion and metastasis of endometrial carcinoma. Methods Immunohistochemistry was used to measure the MMP-2, TIMP-2, and MVD protein levels in 33 patients with endometrial carcinoma and 8 normal endometrial samples. Results The MMP-2, TIMP-2 and MVD protein expressed in both normal endometrial samples and endometrial carcinoma. The positive expression proportions of MMP-2, TIMP-2, and MVD protein in endometrial carcinoma tissues were higher than those in normal endometrial samples (P