Journal of Jilin University(Medicine Edition) 2006;0(01):-

Correlations of matrix metalloproteinase content and expression with invasion and metastasis of hepatocellular carcinoma

Zhichao ZHANG ; Yaxin SUN ; Mingku JIA

Keywords

carcinoma, hepatocellular; gelatinase A/blood; gelatinase A/chemistry; gelatinase B/blood; gelatinase B/chemistry; neoplasm invasion; neoplasm metastasis

Country

China

Language

Chinese

Abstract

Objective To investigate the correlations of serum matrix metalloproteinase-2, -9 (MMP-2, MMP-9) contents and tissue expressions in hepatocellular carcinoma with tumor invasion and metastasis. Methods Serum MMP-2, MMP-9 contents were detected in 40 patient with hepatocellular carcinoma and 20 healthy controls by ELISA; the expressions and distributions of MMP-2 and MMP-9 in 40 patients and 10 normal tissues were detected by immunohistochemical method. Results Serum MMP-2, MMP-9 contents were significantly elevated in cancer samples compared with normal serum (P