Objective To investigate and analysis the situation of malocclusion of 49 skulls of ancient resident in Xinjiang, and discuss the history evolution and the pathologic mechanism of malocclusion. Methods The investigation was carried out based on the standard of individual normal occlusion. Results Among the group of 49 skulls, the morbility rate of malocclusion was 30. 61% ; in Angle's classification of malocclution, class I was the most (73. 33%); in Mao's classification of malocclution, class I was also the most (33. 33%). Conclusion The morbility rate of malocclusion of resident in bronze age is lower than that of modern resident and nearer ages resident. There is a close releationship between the human food construction and the pathogenesis of malocclution.