Chinese Journal of Clinical Laboratory Science 2006;0(01):-

Studies on relationship between resistance to vancomycin and the coagulase activity of S.aureus

Hong DAI ; Xuegong FAN

Keywords

vancomycin; drug resistibility; coagulase

Country

China

Language

Chinese

Abstract

Objective To observe the changes of coagulase activity and the DNA expression of coagulase of S.aureus during inducing vancomycin-resistant S.aureus in vitro.Methods Coagulase activity and DNA expression of coagulase of S.aureus were detected.Results The coagulase activity in 6 strains and the expression of coagulase DNA in 1 strain reduced.Conclusion Decreased coagulase activity and DNA expression are probably linked to vancomycin resistance of S.aureus.