irty elder patients above 65 years were randomly divided into two groups. group I induced with disoprivan 1.5 mg·kg-1and group Ⅱ induced with disoprivan 1.5 mg·kg-1 combined with ephedrine 0.075 mg·kg-1Changes of systolic pressure, diastolic pressure, heart rate, ECG, SpO2 wer eabserved. Every their base values before induction every determining ralues, after induction, and after tracheal intubatton were controlled and statistical an alyzed. Results: Each value after induction and after tra cheal intubatton were lower than their base value (P＜0.05) in two groups, respectirely. The declining ranges of SBP, DBP, HR after induction and after trac heal intubatton in group Ⅱ were lower than that in group Ⅰ, there was a signif icant difference between both groups (P＜0.05). Conclusion:There is a certain using importance that general anaesthesia induced with disoprivan combined with ephedrine 0.075 mg·kg-1to be used for elder patients.