To compare the efficacy on miyalisa n with ribavirin in the treatment of infants' diarrhea. Methods: 152 infants with diarrhea in outpatient department were divided into two groups treated with miyalisan (80 cases) or ribavirin (72 cases) for 3 days. The therapy could be continued for another 3 days if necessary. Results : The Clinically effective rate and the negative conversion rate of rotavirus in the treated group and controlled group were 93.8% and 87%, 82% and 60%, respectively, there were sinnificantly different(P＜0.05) between two g roups. Conclusion: Miyalisan had showed a better efficacy in treatment of infants' rotavivus enteritis than ribavirin.