Journal of Medical Postgraduates 2003;0(11):-

Research progress of correlation between NF-?B and CPB

Jianjun QIAN ; Hua JING

Keywords

Nuclear factor kappa B; Systemic inflammatory response syndrome; Ischemia-reperfusion; Cardiopulmonary bypass

Country

China

Language

Chinese

Abstract

Nuclear factor kappa B(NF-?B) is an important transcription factor in the expression of many inflammatory media. With the recent progress of molecular biological technique, the modulated mechanism of NF-?B in immunity, stress, inflammatory responses, and the differentiation and growth of lymphocyte has been the focus. This review presents the role of NF-?B in ischemia-reperfusion and cardiopulmonary bypass, and the research progression of intervention therapy in inhibition of the activation of NF-?B is also introduced herein after.