Microbiology 1992;0(05):-
EFFECT OF MICROENVIRENMENT ON LIPASE-CATALYZED ENANTIOSELECTIVE ESTERIFICATION OF KETOPROFEN
Wei DU ; Minhua ZONG ; Rong YANG ; Qiong LI ; Yong GUO
Keywords
Microcnvirement, Lipase, Ketoprofen, Kineticresolutt
Country
China
Language
Chinese
Abstract
The effect of reaction media cosolvent water activity, temperature and pH on Novozym 435-caulyzed enantioselective esterification of ketoprofen was systematically explored. Novozym 435 showed high catalytic activity and enantioselectivity in cyclohexane; E value increases markedly by addition of toluene to cyclohexane; the optimum temperature and the initial water activity were found to be 30℃ and 0.09 respectively; pH shows little effect on enzymatic reaction wilson the scope studied.
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