Chinese Journal of Marine Drugs 1994;0(02):-

STUDIES ON TOTAL SYNTHESIS AND STRUCTURE——ACTIVITY RELATIONSHIP OF MARINE ALGA ANTIBIOTIC( - ) -MALYNGOLID IV synthesis of 5 - hydroxymethyl - 5 - benzyl - s -valerolactone

Heping ZENG

Keywords

valerolactone; marine antibiocic analoque; chiral phase transfer catalyst

Country

China

Language

Chinese

Abstract

Title compund have been synthesized from adipic acid (starting material ) in six steps, a chiral phase transfer catalyst (3s,4s)-1-benzyle-1-methyl-3,4 - pyrrolidindiol-onium iodide (PTC) was used to promote the iasymmetric reactions in the key steps of forming chiral centers