Journal of Korean Medical Science  2011;26(6):807-813

doi:10.3346/jkms.2011.26.6.807

Prostate Volume has Prognostic Value Only in Pathologic T2 Radical Prostatectomy Specimens.

In Chang CHO 1 ; Whi An KWON ; Jeong Eun KIM ; Jae Young JOUNG ; Ho Kyung SEO ; Jinsoo CHUNG ; Weon Seo PARK ; Kang Hyun LEE

Affiliations

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Keywords

Prostate; Prostatic Neoplasms; Prostatectomy; Volume

Country

Republic of Korea

Language

English

Abstract

The objective of this study was to evaluate the prognostic roles of the prostate volume, tumor volume, and tumor percentage as a function of the pathologic T stage in radical prostatectomy specimens. This study included 259 patients who underwent radical prostatectomy between 2005 and 2010. The mean follow-up period was 41.2 months. In all of the specimens, prostate volume (P = 0.021), the Gleason score (P = 0.035), and seminal vesicle invasion (P = 0.012) were independent predictors of biochemical recurrence (BCR). In the T2 group, multivariate analysis showed that the BCR was significantly associated with prostate specific antigen (PSA) (P = 0.028), a lower prostate volume (P = 0.004), and the Gleason score (P = 0.040). The Kaplan-Meier survival curve showed that a smaller prostate volume was significantly associated with a greater risk of BCR (< 30 vs > or = 30 mL; P = 0.010). In the T3 group, patients with seminal vesicle invasion had a significantly shorter mean BCR-free survival (P = 0.030). In this study, tumor volume and tumor percentage did not predict BCR. Notably, a lower prostate volume is an independent predictor for BCR only in the organ-confined radical prostatectomy specimens. But, prostate volume could not predict BCR in most locally advanced tumors.