Journal of Korean Medical Science  2011;26(6):824-828

doi:10.3346/jkms.2011.26.6.824

Waldenstrom Macroglobulinemia with CD5+ Expression Presented as Cryoglobulinemic Glomerulonephropathy: A Case Report.

You Lim KIM 1 ; Soo Jung GONG ; Young Hwan HWANG ; Jong Eun JOO ; Young Uk CHO ; Jung Ae LEE ; Su Ah SUNG ; So Young LEE ; Nae Yoo KIM

Affiliations

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Keywords

Waldenstrom Macroglobulinemia; CD5+ Lymphoplasmacytic Lymphoma; Cryoglobulinemic Glomerulonephritis

Country

Republic of Korea

Language

English

Abstract

Waldenstrom macroglobulinemia (WM) is a B-cell lymphoproliferative disorder associated with bone marrow involvement of lymphoplasmacytic lymphoma (LPL) and an IgM monoclonal gammopathy. Generally B-lymphocytes in LPL do not express CD5 that is important for differential diagnosis of B-cell lymphoproliferative disorders. In WM, various renal diseases and type I cryoglobulinemia are well described separately, but cryoglobulinemic glomerulonephropathy is very rarely reported. A 61-yr-old woman complained of generalized edema, cyanosis of the extremities in cold weather, visual disturbance, and pancytopenia. Bone marrow and renal biopsy showed CD5+ expressing B-cells and cryoglobulinemic glomerulonephropathy. With the diagnosis of WM, she received cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy and got complete remission. Here, we report a rare case of WM associated with unusual expression of CD5+ B-lymphocytes and cryoglobulinemic glomerulonephropathy, and emphasize the importance of the clinical features in differentiating CD5+ B-cell lymphoproliferative disorders.