International Journal of Pediatrics 2010;37(2):109-111,148

doi:10.3760/cma.j.issn.1673-4408.2010.02.001

The mechanism of hypoxia-induced persistent pulmonary hypertension of newborn and pulmonary vascular remodeling

Yanping XU ; Lizhong DU

Keywords

Persistent pulmonary hypertension of newborn; Hypoxia; Endothelial cell; Smooth muscle cell; Pulmonary vascular remodeling

Country

China

Language

Chinese

Abstract

Persistent pulmonary hypertension of newborn (PPHN) is a clinical syndrome,characterized by pulmonary arterial pressure elevated relative to systemic blood pressure,leading to extrapulmonary right-to-left shunting of blood across the ductus arteriosus and foramen ovale,causing severe hypoxemia.Pulmonary vascular remodeling is pathognomonic of hypoxia-induced PPHN.The regulatory mechanism and cell composition of vascular wall were dysfunction,which led to vascular wall thickened.The review focus on three aspects,such as endothelial cells,smooth muscle cells,and adventitial cells,described the relation and the possible mechanisms between hypoxia-induced PPHN and pulmonary vascular remodeling.