Objective 500 cases undergoing molybdenum target radiography were analysed retrospectively to improve the image quality. Methods influencing factors of 500 cases molybdenum target CR and clinical pathological data in recent 3 months were analysed. All of the patients take CC,MLO phtotography. The machine applied is Siemens 3000, AGFA galactophore special IP boards, and image postprocessor is AGFA ADC Compact. Results In 500 cases, 89 cases without obvious lesions, 389 case with benign lesion, 113 cases are breast cancer. Conclusion To take a satisfying molybdenum target radiograph, patients' features of breasts such as size and shape resulting in different radiation setting, which is the key to get satisfying images, should be understood.