International Journal of Pediatrics 2012;39(1):105-107,封3

doi:10.3760/cma.j.issn.1673-4408.2012.01.031

Osteoclasts and T-helper cells

Chaobin SHEN ; Qiaoe WANG

Keywords

Osteoimmunology; Osteoclast; T-helper cell; Receptor activator of nuclear factor κB ligand

Country

China

Language

Chinese

Abstract

The interaction between T cell and osteoclasts is important in osteoimmunology.T-helper cells,which produce interleukin-17,induce the expression of receptor activator of nuclear factor κB ligand in synovial cells.Companied by with inflammatory cytokines,they stimulate the differentiation and activation of osteoclasts.Osteoimmunology helps us understand how antirheumatic drugs work,as well as developing new therapeutic strategies for rheumatic diseases.