Journal of International Oncology 2008;35(7):489-490,493

Correlation between P-glycoprotein and CD44 in cancer

Weifeng KE

Keywords

P-glycoprotein; Antigens,CD44; Drug resistance,neoplasm; Neoplasm invasiveness; Neoplasm metastasis

Country

China

Language

Chinese

Abstract

P-glycoprotein(P-gp)and CD44 have been characterized and are known to be determinants of multidrug resistance(MDR)and cancer metastases.Recent researches suggest that there is a correlation between P-glycoprotein(MDR)and CD44(invasion and metastases).A better understanding of any relationship between drug resistance and tumor metastasis may lead to more effective tumor treatment.