Objective: To explore the value of integrated backscatter(IBS) of kidney with different dosage of organophosphorus in rabbits. Methods: Animal models of organophosphorus poisoning were established. Ultrasonographic examinations were performed on four different dosage experimental groups and control group at 1h and 3 h after rabbits being poisoned.The echo and the size of kidney were evaluated by two-dimensional ultrasound.The changes of parenchyma were quantitatively analyzed by IBS.Results: No significant changes were found in kidney echo of any groups.With the increasing dosage and prolonging time of poisoning,significant changes were found in volume and length of kidneys comparing with that of control group(P