Objective:To evaluate the efficacy and safety of moxifloxaction and levofloxaction in the treatment of the lower respiratory tract inflection.Method:64 cases patients were randomly divided into two groups.The clinical trial group was treated with moxifloxaction 400mg once a day,orally for 7-10 days and the controlled group treated with levo- floxaction in 200mg twice a day for 7-10 days.Result:The effective rate of the moxifloxaction group(93.9%)was high- er than that of the levofloxaction group(71.8%),but not significantly.The recovery rate of the moxifloxaction group (71.8%)was significantly higher than that of the levofloxaction group(46.9%);the days of recovery of clinical symptoms were not significantly different in the two groups.There was no significant difference between the two groups in the bacterial eradication rate.Conclusion:Moxifloxaction is effective and safe in the treatment of the lower respiratory tract inflection.