Journal of the Korean Association of Oral and Maxillofacial Surgeons  2010;36(1):16-22

doi:10.5125/jkaoms.2010.36.1.16

The effect of hyaluronic acid on anti-inflammatory action in mouse.

Sang Kyun KIM 1 ; Hyung Seok LEE ; Kwang Seob BYEON ; Young Joo LEE ; Soon Min HONG ; Mee Ra CHOI ; Jun Woo PARK

Affiliations

+expand

Keywords

Hyaluronic acid; Anti-inflammatory agent; Mice

Country

Republic of Korea

Language

Korean

Abstract

PURPOSE: The purpose of this study was not only to evaluate the relative mRNA expression of interleukin-1beta(IL-1beta), cyclooxygenase2 (COX-2) and prostaglandin E2 (PGE2) by RT-PCR analysis but to observe pattern of edema by light microscopic and electron microscope after topical apply of hyaluronic acid in inflammation-guided mouse. MATERIAL AND METHODS: Mice of this study were devided into 4 groups: Control group (no inflammation guided), Positive control (inflammation guided + vaselin apply), Protopic group (inflammation guided + protopic apply), Hyaluronic group (inflammation guided + hyaluronic acid apply). RESULTS: Hyaluronic group showed less expressions of IL-1beta, COX-2, PGE2 than those of positive control & protopic group. Hyaluronic group revealed a decreased inflammation than positive control & protopic group in Light Microscope. Hyaluronic group appeared decreased edema of ear compare to positive control & protopic group in Elecron Microscope. CONCLUSION: It was considered that hyaluronic acid has an antiinflammatory effect for intercepting the gene expression of cytokines related to inflammation.