A study of the mutagenieity of SAGS preservative solution for red cells,performed by Ames method, was reported.Result of the study in- dicated that there was no evidence of the positive mutagenicity reaction of SAGS preservative solution for red cells at its 6 doses ranging from 0.02 to 100mg/ml,whether the rat liver microsomal enzymes(S9)were added as metabolic activators or not.That is, the solution was unable to inducethe mutation at gene loci in the strains tested by Ames Method.