Annals of Dermatology  2006;18(2):91-96

doi:10.5021/ad.2006.18.2.91

A Case of Secondary Cutaneous Diffuse Large B-Cell Lymphoma.

Jung Keun KIM 1 ; Tack Hun KIM ; Tae Ho PARK ; Jae Hak YOO ; Kea Jeung KIM

Affiliations

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Keywords

Bcl-2; Post-GC B-cell; Secondary cutaneous diffuse large B-cell lymphoma

Country

Republic of Korea

Language

English

Abstract

We report here on a case of secondary cutaneous diffuse large B-cell lymphoma (DLBCL) that occurred in a 67-year-old man who had a 2-month history of nodular growing masses on the left cheek, plus palpable lymph nodes on the left cervical area. The histopathological findings showed a diffuse infiltration of large atypical lymphocytes with nuclear atypia throughout the entire dermis. These showed positive CD20, bcl-2 and the post-germinal center marker, MUM-1. According to the WHO (World Health Organization) classification, this lymphoma is considered to be diffuse large B-cell lymphoma of the post-germinal center (GC) B-cell type with a secondary cutaneous manifestation. We treated the patient with systemic chemotherapy (CHOP) and anti-CD20 monoclonal antibodies. During the course of treatment, new skin lesions developed on his neck, so we changed the regimen to cytosin- arabinoside and cisplatin. But he died of pneumonia after the third cycle.