Korean Journal of Fertility and Sterility  2000;27(2):179-182

The Analysis of LHbeta -subunit Variants in Infertile Patients with Premature Ovarian Failure (POF) in Korea.

Eu Gene LEE ; Nam Keun KIM ; Sook Hwan LEE ; Jung Jae KO ; Kwang Yul CHA ; Hye Sun JEON ; Kyung Ah LEE

Country

Republic of Korea

Language

Korean

Abstract

This study was performed to determine whether the LHbeta -subunit gene missense mutation is present in Korean infertile patients with 46,XX POF women. The variants of LHbeta exon 2 (Trp 8Arg; TGG to CGG and Ile15Thr; ATC ti ACC) were studied in forty-four 46.XX idiopathic POF and 54 nonpregnant women. The LHbeta exon 2 variants were more frequent in POF patients (20.5%) than nonpregnant( 16.7%) women (p>0.05). POF patients with the variant was slightly higher than nonpregnant women with the variant.