Experimental & Molecular Medicine  2015;47(3):e150-

doi:10.1038/emm.2014.122

The role of mitochondrial DNA mutation on neurodegenerative diseases.

Moon Yong CHA 1 ; Dong Kyu KIM ; Inhee MOOK-JUNG

Affiliations

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Country

Republic of Korea

Language

English

Abstract

Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may result in greater reactive oxygen species production, triggering a circular chain of events. However, the mechanisms underlying this vicious cycle have yet to be fully investigated. In this review, we summarize the relationship of oxidative stress-induced mitochondrial dysfunction with mtDNA mutation in neurodegenerative disorders.