Objective To study the influencing factors of occupational musculoskeletal injuries(OMSI)in nurses from operation room.Method By convenience sampling,300 nurses from the operation rooms of 8 First Class Grade A hospitals in Shenzhen were involved in the study.Results The age for first onset of OMSI in the nurses was(31.6±6.8)years,with a prevalence rate of 81.3%.The back,waist and shoulder were the most vulnerable for their highest prevalence.The influencing factors included age,seniority,overweight,lack of resting time,lack of notice of muscle relaxation and physical exercise and inadequacy of post shifting.Conclusions The prevalence of OMSI in nurses from operation rooms is higher.Besides age,seniority and BMI,it is closely related with occupational risk factors and occupational management factors.