Pain of recent side effects including a children's breathing,circulation,metabolism,immune and nervous system.The long-term side effects including mental,physical and mental growth,development,behavior and so on.Pain at the same time,the children will also have a negative impact to their families and the society.Implementation of analgesia and sedation therapy for children and is therefore clinicians morality and responsibility,need to clinicians from the perspective of professional and humane thinking and understanding.Use of analgesic and sedation therapy to keep children safe and comfortable is the most basic link in PICU treatment.