Objective To observe the effects of misoprostol on prevention of postpartum hemorrhage.Methods 200 cases of full-term pregnancy intravaginal labor were randomly divided into misoprostol groups (n=100) and control groups (n=100).The misoprostol groups were treated with misoprostol 400 μg PO after labor and control groups were treated with oxytocin 20 U IV after labor.Results The average time interval of the third stage was (6.10±3.35) min in misoprostol groups,whereas (10.00±3.45) min in controls.There was significant difference between two groups (P＜0.01).The average quantity of blood loss in 2 h after labor was (150.30±34.00) ml in misoprostol groups,whereas (240.60±57.30) ml in controls.Conclusion Better effects of misoprostol than oxytocin were proved on preventing postpartum hemorrhage.