Journal of Guangzhou University of Traditional Chinese Medicine 1999;0(02):-

Effect of Kebimin Spray on Substan on Substance P Contents in Lung and Plasma of Guinea Pigs with Hhypersensitive Rhinitis

Yanfang QIAN ; Bingwen LI ; Zhengmou ZHOU ; Yanyan BAO ; Jinrang LI

Keywords

＠KEBIMIN SPRAY/pharmacol.; RHINITIS, ALLERGIC, PERENNIAL/TCD ther.; ADMINISTRATION,INTRANASAL; SUBSTANCE P/blood

Country

China

Language

Chinese

Abstract

To study the antisensitiZation of Chinese drug, Inodel gUinea pigS with hypersensitive thinilistabbed with Kebindn Sray Served as Group l, and substance P(SP) contents in lung and plasma ofGroup I were detected and compared with normal coned group (Group 11),model control groUp(Group ill) and poSitive medicine control group(GrouP ac).The resultS showed that SP content inlung and plasma of Group ill were higher than thais of GrouP 11(P 0.05).SP is an active neuropeptide and over release of SP Inay result in hperetion of the nose.It is indicated that Kebimin SPlaycan inhibit type I alleds by decreasing SP contents in lung and plasma.