Serum sialy transferase(ST) and fucosyltransferase(FT) were determinated in 56 patients with nasopharyngeal or laryngeal carcinoma. 18 healthy were normal control. Serum sialic acid and fucose were also determinated in each sample.Comparison were made statistically among groups of stages of cancer, having metastases or no metastases, before treatment,and recurrence or non-recuurrence after cure Our results suggest that determinations of serum ST, FT, sialic acid and fucose could be used as new-indicators of diagnosis f.or advanced nasopharyngeal or laryngeal cancer and differentiation between recurrence and non-recurrence after treatment. However,the levels of ST in serum could be evaluated for metastases or non-metastases before treatment