A series of 61 patients are presented, among them 38 patients(twenty with cancer of esophagus, two with cancer of cardia, four with cancer of the upper part of st- omach, and radical resection were done in all of them)have been supported by TPN during perioperative and postoperative period, none of leakage at the anastomostic stoma occured; five paients with external fistulas of the alimentary tract supported by TPN healed spontaneously in four, operative closure of fistula was necessary in one, and all were cured. TPN was used in other 18 patients with miscellaneous disease, among them two of the patients with acute haemorrhagic pancreatitis were cured.One patient with major nutritional problem is presented in detail, for whom TPN had been continued for 225 days.