Objective:This study was aimed to explore the apoptotic effect the K562 cells treated by resveratrol and/or arabinosylcytosin.Methods:Fas/FasL expressian was detected by immunohistochemical method and survivin expression was detected by RT-PCR in K562 cells,48 hours after treatment by resveratrol and arabinosylcytosin respectively.Results: Fas/FasL expression in K562 cells,treated by resveratrol and arabinosylcytosin respectively,was significantly increased compared with the control group(P0.05),contrary to FasL expression(P0.05).Conclusions:In conclusion the resveratrol and/or arabinosylcytosin could upregulate Fas/FasL expression and activate the apoptosis pathway of Fas/FasL to induce the apoptosis of K562 cells.It could downregulate the expression of survivin to promote apoptosis.The two drugs had synergistic effect.