The definition of pheochromacytoma is the tumor derived from the adrenal chromaffin cell excessive producing catecholamines.Until now,the urine and plasma metanephrines(MNs) determined by HPLC-ED is considered as the first choice for the biochemical diagnosis of pheochromacytoma.According to the clinical pathway,the location of pheochromocytoma is determined by imaging methods including CT,MRI and PET,however,123I-MIBG is a more specific method for location of the tumor.The candidate genes screening including RET,VHL,SDHD,SDHB and NF1 have been recommended.The surgery to remove the tumor is the first choice for curing of pheochromacytoma.