Objective To study the relationship between the prevalence and the clinics,histology of autoantibodies in patients with nonalcoholic steatohepatitis.Methods This study was based on data related to 117 patients with NASH who were treated at the Departments of Youan Hospital between 2000 and 2005.The prevalence of autoantibodies in all patients were examined and the relationships were analyzed with sex,age,liver function,lipid index and liver biopsy.Results The prevalence of autoantibodies in 117 patients with NASH was 35%,29.1% of whom were ANA and/or SMA positive,higher than in the general population(6%~15%);ANA and/or SMA positive patients with NASH were older and mostly females as compared to ANA and/or SMA negative patients,but there were no significant differences in liver function,lipid index and liver biopsy between positive and negative patients.Conclusion ANA and/or SMA are common in NASH patients and often represent a nonspecific antibody response that is not associated with the severity of liver injury.