Objective: To study Blood Stasis Syndrome by molecular-biology in kidney-deficiency of diabetes pedigree.Methods: 18 members in diabetes pedigree were closed to make routine physical & chemical test and the macroscopic diagnosis of kidney-deficiency and blood stasis,3 diabetics with blood stasis syndrome and 2 healthy people in the same family,were selected to make 14000 genes chips hybrid test.Results: The pedigree maps and the comparative syndrome score tables of kidney-deficiency and blood stasis syndrome were obtained,and the 446 genes of different expressions,in particular,5 genes such as the TBXAS1,which was used to illustrate the possibility of effects on the blood stasis were also selected Conclusion: There was an exceeding preponderance of pedigree research method,which was used to search the macroscopic syndrome and the microscopic expressions of different genes.And it would help us to understand the relationship between the syndrome of kidney-deficiency & blood stasis diabetes and the genes of different expressions.