Acta Nutrimenta Sinica 1956;0(03):-

INHIBITION OF GASTRIC CANCER CELLS INVASION AND METASTASIS BY GENISTEIN IN VITRO

Junwen ZHANG ; Pilong WANG

Keywords

gastric cancer cells; genistein; invasion and metastasis; TGF- 1

Country

China

Language

Chinese

Abstract

Objetive: To study the effect of genistein on the invasion and metastasis of human gastric cancer cells SGC-7901 in vitro. Method: MTT was used to study the effects of adhesion by genistein on SGC-7901. The Boyden Chamber membrane invasion culture system was used to study invasion and metastasis. Cell-immunochemistry was used to observe the change of TGF- 1. Results: In the membrane invasion culture system, the numbers of invading and migrating SGC-7901 cells were significantly lower in genistein treated groups than those in the control groups (P