Chinese Journal of Clinical Pharmacology and Therapeutics 2002;0(06):-

Effect of sodium-calcium exchanger and its inhibitors on arrhythmia

Lei SHEN ; Yulin WU

Keywords

sodium-calcium exchanger; reverse mode; calcium overload; sodium-calcium exchanger inhibitor; arrhythmia

Country

China

Language

Chinese

Abstract

In cardiomyocytes,sodium-calcium exchanger(NCX) is regarded to play an important role in the regulation of intracellular Ca~(2+) concentration.During the cardiac ischemia/reperfusion or cardenolide intoxication,the inflow Ca~(2+) through NCX reverse mode induce calcium overload and arrhythmia.Recently,the benzyloxyphenyl derivatives have been developed as selective NCX inhibitors,which may have therapeutic potential as a new remedy for arrhythmias.