AIM: To evaluate the protective effect on rabbit's postoperative pericardial adhesion of ligustrazine and sodium hyaluronate on adhesions,pathological histology,fibrinogen and white blood cells.METHODS: Rabbits were randomly divided into five groups,24 rabbits were used to make model with pericardial adhesions to four groups.Sodium hyaluronate group was injected with 5 mg sodium hyaluronate to pericardial cave of each rabbit after the operation;ligustrazine group was injected(6.7)(mg?kg~(-1)) ligustrazine to vein after the operation,qd,7 d enough;equal quantity of normal saline was injected in model group and sham operation group.The rabbits were sacrificed 20 days later.Adhesions tissues and pathological morphous were observed and analysis were done,FIB and WBC were tested at 7 d time point.RESULTS: Pericardial adhesions and fiber hyperplasia were significant in model group.Compared with sham group,the concentration of FIB and the amount of WBC were obviously increasing(P(0.05)).CONCLUSION: These results demonstrate that sodium hyaluronate and ligustrazine can effectively prevent postoperative pericardial adhesion.The protective effect is,to some degree,related to the inhibition of FIB and WBC.