Chinese Journal of Clinical Pharmacology and Therapeutics 2002;0(06):-

Effects of chloride channel blocker on hypoxia induced rat pulmonary hypertension

Biwen MO ; Jinrong ZENG ; Guojian LI ; Wenxin HUANG ; Fang YU ; Jiying WANG ; Changming WANG

Keywords

tamoxifen; hypoxia pulmonary hypertension; hypoxia

Country

China

Language

Chinese

Abstract

AIM: To investigate the therapeutic effect of chloride channel blocker tamoxifen on hypoxia pulmonary hypertension in rats.METHODS: Sixty male Wistar rats were randomly divided into therapeutic group(H/Q group),hypoxia group(H group),normal control group(C group).Mean pulmonary artery pressure(mPAP),the ratio of the weight of right ventricle to that of left ventricle plus septum[RV(LV+S)],and the ratio of the pulmonary arteriole wall area to that of vascular total area(WA/TA),were measured at 4,7,14,21 days.RESULTS:The mPAP began to increase from 7 days,and reached peak at 21 days in hypoxia group,however it is obviously lower in therapeutic group at same time.The ratio of RV(LV+S) began to increase from 14 days,and reached peak at 21 days in hypoxia group,however it is obviously lower in therapeutic group at same time.The ratio of WA/TA at 21 days in hypoxia group was significantly higher than therapeutic group,respectively(P