International Journal of Cerebrovascular Diseases 2006;0(01):-

Pathophysiology and Apoptosis in Ischemic Stroke

Xinsheng DING ; Meijiang FENG

Keywords

ischemic stroke; excitatory amino acid; free radical; calcium overload; gene; apoptosis; penumbra

Country

China

Language

Chinese

Abstract

Ischemic stroke is a very complex disorder with many intracellular and extracellular factors such as excitatory amino acids, free radicals, calcium overload, apoptotic genes and inflammation involved in its pathophysiological mechanisms. It has been reported that neuronal death mainly derives from necrosis and/or apoptosis after cerebral ischemia. Those neurons in the ischemic core usually suffer from necrosis, however, apoptosis (also referred to as delayed neuronal death) occurs in the ischemic penumbra, which has been the major therapeutic target in the ischemic stroke.