Chinese Pharmaceutical Journal 1999;(3):160-

Anti-asthmatic effect inhibition of artesunate on the asthmatic model of guinea-pig

Maosheng YANG ; Kang HE ; Weiming XU

Keywords

artesunate; asthmatic model of guinea-pig; aminophylline; acetylcholine; histamine

Country

China

Language

Chinese

Abstract

OBJECTIVE：To study the anti-asthmatic effects of artesunate on the durg-induced asthmat.METHOD:Drug-induced asthmatic model of guinea-pig. RESULTS:Using nubilous inhalation or intragastric administration,artesunate significantly inhibited the guinea-pig model asthma in a dose-dependent manner.It's ED50 were (99.95±7.69)mg.L-1(n=4) and (15.64±1.25)mg.kg-1.d-1(n=4) respectively. CONCLUSION:artesunate showed anti-athmatic effect in guinea-pig asthmatic model.