Journal of International Oncology 2012;(11):824-826,880

doi:10.3760/cma.j.issn.1673-422X.2012.011.008

Pirh2 and tumor

Xiaorong WU ; Dongming LIU

Keywords

Neoplasms; Ubiquitin-protein ligases; Pirh2

Country

China

Language

Chinese

Abstract

Pirh2 (p53-induced protein with a Ring-H2 domain),one of the ubiquitin-protein E3 ligases,can promote p53 degradation via ubiquitin-proteasome pathway,and repress the biological functions of p53.Researchers have found that the Pirh2 is overexpressed in many cancers,which suggests Pirh2 is probably correlated with tumorigenesis and cancer development,and it may become a promising cancer therapeutic target.