Chinese Journal of Respiratory and Critical Care Medicine 2003;0(02):-

Effect of Bacillus Calmette-guerin vaccine on apoptosis of lymphocytes in athmatic BALA/c mice

Yianliang YU ; Xiuming SUN ; Cuili LI

Keywords

Asthma; Apoptosis; Bacillus Calmette guerin vaccine; Lymphocytes

Country

China

Language

Chinese

Abstract

Objective To explore the effect of Bacillus Calmette guerin vaccine (BCG) on apoptosis of lymphocytes in asthmatic BALC/c mice Methods Asthmatic BALB/c mice model established by inhaling ovalbumin was treated by BCG Lymphocytes apopotic index and DNA damage index were determined by comet method and xylidine method,respectively Results Apoptosis index and DNA damage percentage of peripheral blood and BALF lymphocytes were significantly elevated after BCG treatment( P