Chinese Journal of Respiratory and Critical Care Medicine 2003;0(01):-

Effects of thalidomide on the expressions of basic fibroblast growth factor in human lung adenocarcinoma cell line A_(549) and cisplatin-resistant cell line A_(549) DDP

Xiping LI ; Xuyi LIU ; Jie WANG

Keywords

Lung cancer; Thalidomide; Basic fibroblast growth factor

Country

China

Language

Chinese

Abstract

Objective To elucidate the effects of thalidomide on the expressions of basic fibroblast growth factor(bFGF) in parental and cisplatin resistant human lung adenocarcinoma cell line A 549 and A 549 DDP Methods RT PCR and lmmunohistochemistry were used to detect the bFGF mRNA and protein expression in A 549 and A 549 DDP Results bFGF mRNA expression levels and protein expressions in A 549 and A 549 DDP were all significant reduced after treatment of thalidomide (6 ?g/ml)(all P